There is a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to reduce afferent agony transmission and deliver analgesia. Thus, medication like clonidine that concentrate on alpha-2 receptors can affect the transmission of ache. Clonidine is distributed in breast milk; https://jamesu364rfx4.buyoutblog.com/profile