Analysis into conolidine has triggered discovery of the opioid receptor in the body identified as ACKR3/CXCR7. ACKR3 appears to be the most wanted goal for conolidine, which also disregards another 4 classical opioid receptors(3). Conolidine has been present in the tabernaemontana divaricata plant, and that is within the Apocynaceae https://archerenegf.dbblog.net/10957510/alternative-natural-pain-relief-to-replace-traditional-painkillers-options