Conolidine’s analgesic effects stem from its interaction with non-opioid pain pathways. As opposed to opioids, which bind to µ-opioid receptors inside the central nervous system, conolidine modulates alternate molecular targets. A Science Advances study uncovered that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://angeloscjsa.blogdon.net/not-known-factual-statements-about-conoldine-alternative-natural-pain-relief-54690823